Dissolution-/Permeation-Analysis of Marketed Fenofibrate Nano- and Microparticle Formulations for Prediction of Oral Bioavailability: A Proof of Concept Study
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منابع مشابه
Enhanced oral bioavailability of fenofibrate using polymeric nanoparticulated systems: physicochemical characterization and in vivo investigation
BACKGROUND The intention of this research was to prepare and compare various solubility-enhancing nanoparticulated systems in order to select a nanoparticulated formulation with the most improved oral bioavailability of poorly water-soluble fenofibrate. METHODS The most appropriate excipients for different nanoparticulated preparations were selected by determining the drug solubility in 1% (w...
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The aim of the present study was to make a fenofibrate (FNB) nanocrystal (NC) by wet media milling, characterizations and formulates into oral strip-films (OSFs). Mechanical properties, redispersion study, and solid-state characterizations results suggested that reduction of drug crystal size at nanoscale and incorporation into OSFs does not affect the solid-state properties of the drug. In vit...
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